Gwenaëlle Douaud

Details

Position: Associate Professor
Department: Department of Clinical Neurology
Institution: University of Oxford
Address: FMRIB Centre, John Radcliffe Hospital, Oxford OX3 9DU
Phone: 01865 222 717
Home page: http://www.ndcn.ox.ac.uk/team/gwenaelle-douaud
E-mail: douaud at fmrib.ox.ac.uk

Further information

I received my PhD from the University of Paris XI-Orsay in 2006, where I worked on structural and diffusion imaging of Huntington's disease and neuronal grafts under the supervision of Prof. Philippe Remy and Dr Philippe Hantraye. Since then, I have been working at the FMRIB centre, Oxford, first as a post-doctoral researcher and now as a research fellow.

Being at the interface between basic neuroscience, methodological imaging development and clinical application is really what I enjoy the most. My body of work focuses on translational research from imaging methods to applied human neuroscience, such as brain maturation and ageing, and with a particular emphasis on neurodegenerative disorders (Alzheimer's disease, movement disorders and motor neuron disease).

I was recently awarded a 5-year MRC Career Development Fellowship to work on the structural and functional connectivity of the basal ganglia in health and movement disorders (Huntington's and Parkinson's disease) using high resolution MRI.

Publications

Please note that the following is an automatically retrieved selection of papers relating to diffusion MRI, and is not a complete list of publications by this author.

Pflanz CP, Charquero-Ballester M, Majid DSA, Winkler AM, Vallee E, Aron AR, Jenkinson M, Douaud G (2019). One-year changes in brain microstructure differentiate preclinical Huntington's disease stages. Neuroimage Clin 25:102099. [PubMed]
Lawrence TP, Steel A, Ezra M, Speirs M, Pretorius PM, Douaud G, Sotiropoulos S, Cadoux-Hudson T, Emir UE, Voets NL (2019). MRS and DTI evidence of progressive posterior cingulate cortex and corpus callosum injury in the hyper-acute phase after Traumatic Brain Injury. Brain Inj 33(7):854-868. [PubMed]
Le Heron C, Manohar S, Plant O, Muhammed K, Griffanti L, Nemeth A, Douaud G, Markus HS, Husain M (2018). Dysfunctional effort-based decision-making underlies apathy in genetic cerebral small vessel disease. Brain 141(11):3193-3210. [PubMed]
Harms MP, Somerville LH, Ances BM, Andersson J, Barch DM, Bastiani M, Bookheimer SY, Brown TB, Buckner RL, Burgess GC, Coalson TS, Chappell MA, Dapretto M, Douaud G, Fischl B, Glasser MF, Greve DN, Hodge C, Jamison KW, Jbabdi S, Kandala S, Li X, Mair RW, Mangia S, Marcus D, Mascali D, Moeller S, Nichols TE, Robinson EC, Salat DH, Smith SM, Sotiropoulos SN, Terpstra M, Thomas KM, Tisdall MD, Ugurbil K, van der Kouwe A, Woods RP, Zollei L, Van Essen DC, Yacoub E (2018). Extending the Human Connectome Project across ages: Imaging protocols for the Lifespan Development and Aging projects. Neuroimage 183:972-984. [PubMed]
Alfaro-Almagro F, Jenkinson M, Bangerter NK, Andersson JLR, Griffanti L, Douaud G, Sotiropoulos SN, Jbabdi S, Hernandez-Fernandez M, Vallee E, Vidaurre D, Webster M, McCarthy P, Rorden C, Daducci A, Alexander DC, Zhang H, Dragonu I, Matthews PM, Miller KL, Smith SM (2018). Image processing and Quality Control for the first 10,000 brain imaging datasets from UK Biobank. Neuroimage 166:400-424. [PubMed]
Rowland MJ, Ezra M, Winkler A, Garry P, Lamb C, Kelly M, Okell TW, Westbrook J, Wise RG, Douaud G, Pattinson KT (2019). Calcium channel blockade with nimodipine reverses MRI evidence of cerebral oedema following acute hypoxia. J Cereb Blood Flow Metab 39(2):285-301. [PubMed]
Lin RL, Douaud G, Filippini N, Okell TW, Stagg CJ, Tracey I (2017). Structural Connectivity Variances Underlie Functional and Behavioral Changes During Pain Relief Induced by Neuromodulation. Sci Rep 7:41603. [PubMed]
Miller KL, Alfaro-Almagro F, Bangerter NK, Thomas DL, Yacoub E, Xu J, Bartsch AJ, Jbabdi S, Sotiropoulos SN, Andersson JL, Griffanti L, Douaud G, Okell TW, Weale P, Dragonu I, Garratt S, Hudson S, Collins R, Jenkinson M, Matthews PM, Smith SM (2016). Multimodal population brain imaging in the UK Biobank prospective epidemiological study. Nat Neurosci 19(11):1523-1536. [PubMed]
Wu W, Poser BA, Douaud G, Frost R, In MH, Speck O, Koopmans PJ, Miller KL (2016). High-resolution diffusion MRI at 7T using a three-dimensional multi-slab acquisition. Neuroimage 143:1-14. [PubMed]
Foxley S, Jbabdi S, Clare S, Lam W, Ansorge O, Douaud G, Miller K (2014). Improving diffusion-weighted imaging of post-mortem human brains: SSFP at 7 T. Neuroimage 102 Pt 2:579-89. [PubMed]
Frost R, Jezzard P, Douaud G, Clare S, Porter DA, Miller KL (2015). Scan time reduction for readout-segmented EPI using simultaneous multislice acceleration: Diffusion-weighted imaging at 3 and 7 Tesla. Magn Reson Med 74(1):136-149. [PubMed]
Menke RA, Korner S, Filippini N, Douaud G, Knight S, Talbot K, Turner MR (2014). Widespread grey matter pathology dominates the longitudinal cerebral MRI and clinical landscape of amyotrophic lateral sclerosis. Brain 137(Pt 9):2546-55. [PubMed]
Smith SM, Beckmann CF, Andersson J, Auerbach EJ, Bijsterbosch J, Douaud G, Duff E, Feinberg DA, Griffanti L, Harms MP, Kelly M, Laumann T, Miller KL, Moeller S, Petersen S, Power J, Salimi-Khorshidi G, Snyder AZ, Vu AT, Woolrich MW, Xu J, Yacoub E, Ugurbil K, Van Essen DC, Glasser MF (2013). Resting-state fMRI in the Human Connectome Project. Neuroimage 80:144-68. [PubMed]
Douaud G, Menke RA, Gass A, Monsch AU, Rao A, Whitcher B, Zamboni G, Matthews PM, Sollberger M, Smith S (2013). Brain microstructure reveals early abnormalities more than two years prior to clinical progression from mild cognitive impairment to Alzheimer's disease. J Neurosci 33(5):2147-55. [PubMed]
Tziortzi AC, Haber SN, Searle GE, Tsoumpas C, Long CJ, Shotbolt P, Douaud G, Jbabdi S, Behrens TE, Rabiner EA, Jenkinson M, Gunn RN (2014). Connectivity-based functional analysis of dopamine release in the striatum using diffusion-weighted MRI and positron emission tomography. Cereb Cortex 24(5):1165-77. [PubMed]
Steele CJ, Scholz J, Douaud G, Johansen-Berg H, Penhune VB (2012). Structural correlates of skilled performance on a motor sequence task. Front Hum Neurosci 6:289. [PubMed]
Groves AR, Smith SM, Fjell AM, Tamnes CK, Walhovd KB, Douaud G, Woolrich MW, Westlye LT (2012). Benefits of multi-modal fusion analysis on a large-scale dataset: life-span patterns of inter-subject variability in cortical morphometry and white matter microstructure. Neuroimage 63(1):365-80. [PubMed]
Matthews PM, Filippini N, Douaud G (2013). Brain structural and functional connectivity and the progression of neuropathology in Alzheimer's disease. J Alzheimers Dis 33 Suppl 1:S163-72. [PubMed]
de Ruiter MB, Reneman L, Boogerd W, Veltman DJ, Caan M, Douaud G, Lavini C, Linn SC, Boven E, van Dam FS, Schagen SB (2012). Late effects of high-dose adjuvant chemotherapy on white and gray matter in breast cancer survivors: converging results from multimodal magnetic resonance imaging. Hum Brain Mapp 33(12):2971-83. [PubMed]
Douaud G, Filippini N, Knight S, Talbot K, Turner MR (2011). Integration of structural and functional magnetic resonance imaging in amyotrophic lateral sclerosis. Brain 134(Pt 12):3470-9. [PubMed]
Miller KL, McNab JA, Jbabdi S, Douaud G (2012). Diffusion tractography of post-mortem human brains: optimization and comparison of spin echo and steady-state free precession techniques. Neuroimage 59(3):2284-97. [PubMed]
Miller KL, Stagg CJ, Douaud G, Jbabdi S, Smith SM, Behrens TEJ, Jenkinson M, Chance SA, Esiri MM, Voets NL, Jenkinson N, Aziz TZ, Turner MR, Johansen-Berg H, McNab JA (2011). Diffusion imaging of whole, post-mortem human brains on a clinical MRI scanner. Neuroimage 57(1):167-181. [PubMed]
Douaud G, Jbabdi S, Behrens TE, Menke RA, Gass A, Monsch AU, Rao A, Whitcher B, Kindlmann G, Matthews PM, Smith S (2011). DTI measures in crossing-fibre areas: increased diffusion anisotropy reveals early white matter alteration in MCI and mild Alzheimer's disease. Neuroimage 55(3):880-90. [PubMed]
Filippini N, Douaud G, Mackay CE, Knight S, Talbot K, Turner MR (2010). Corpus callosum involvement is a consistent feature of amyotrophic lateral sclerosis. Neurology 75(18):1645-52. [PubMed]
Tomassini V, Jbabdi S, Kincses ZT, Bosnell R, Douaud G, Pozzilli C, Matthews PM, Johansen-Berg H (2011). Structural and functional bases for individual differences in motor learning. Hum Brain Mapp 32(3):494-508. [PubMed]
Giorgio A, Watkins KE, Chadwick M, James S, Winmill L, Douaud G, De Stefano N, Matthews PM, Smith SM, Johansen-Berg H, James AC (2010). Longitudinal changes in grey and white matter during adolescence. Neuroimage 49(1):94-103. [PubMed]
McNab JA, Jbabdi S, Deoni SC, Douaud G, Behrens TE, Miller KL (2009). High resolution diffusion-weighted imaging in fixed human brain using diffusion-weighted steady state free precession. Neuroimage 46(3):775-85. [PubMed]
Douaud G, Behrens TE, Poupon C, Cointepas Y, Jbabdi S, Gaura V, Golestani N, Krystkowiak P, Verny C, Damier P, Bachoud-Levi AC, Hantraye P, Remy P (2009). In vivo evidence for the selective subcortical degeneration in Huntington's disease. Neuroimage 46(4):958-66. [PubMed]
Giorgio A, Watkins KE, Douaud G, James AC, James S, De Stefano N, Matthews PM, Smith SM, Johansen-Berg H (2008). Changes in white matter microstructure during adolescence. Neuroimage 39(1):52-61. [PubMed]
Douaud G, Smith S, Jenkinson M, Behrens T, Johansen-Berg H, Vickers J, James S, Voets N, Watkins K, Matthews PM, James A (2007). Anatomically related grey and white matter abnormalities in adolescent-onset schizophrenia. Brain 130(Pt 9):2375-86. [PubMed]
Houenou J, Wessa M, Douaud G, Leboyer M, Chanraud S, Perrin M, Poupon C, Martinot JL, Paillere-Martinot ML (2007). Increased white matter connectivity in euthymic bipolar patients: diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex. Mol Psychiatry 12(11):1001-10. [PubMed]