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Mara Cercignani

Details

Position: Professor of Medical Physics
Department: Clinical Imaging Science Centre
Institution: Brighton and Sussex Medical School
Address: Clinical Imaging Sciences Centre, Brighton & Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9RR
Phone: +44 (0)1273 87 7879
Home page: http://www.bsms.ac.uk/research/our-researchers/mara-cercignani/
E-mail: m.cercignani at bsms.ac.uk

Publications

Please note that the following is an automatically retrieved selection of papers relating to diffusion MRI, and is not a complete list of publications by this author.

• Gabel MC, Broad RJ, Young AL, Abrahams S, Bastin ME, Menke RAL, Al-Chalabi A, Goldstein LH, Tsermentseli S, Alexander DC, Turner MR, Leigh PN, Cercignani M (2020). Evolution of white matter damage in amyotrophic lateral sclerosis. Ann Clin Transl Neurol 7(5):722-732. [PubMed]
• Toniolo S, Serra L, Olivito G, Caltagirone C, Mercuri NB, Marra C, Cercignani M, Bozzali M (2020). Cerebellar White Matter Disruption in Alzheimer's Disease Patients: A Diffusion Tensor Imaging Study. J Alzheimers Dis 74(2):615-624. [PubMed]
• Barritt AW, Gabel MC, Cercignani M, Leigh PN (2018). Emerging Magnetic Resonance Imaging Techniques and Analysis Methods in Amyotrophic Lateral Sclerosis. Front Neurol 9:1065. [PubMed]
• Broad RJ, Gabel MC, Dowell NG, Schwartzman DJ, Seth AK, Zhang H, Alexander DC, Cercignani M, Leigh PN (2019). Neurite orientation and dispersion density imaging (NODDI) detects cortical and corticospinal tract degeneration in ALS. J Neurol Neurosurg Psychiatry 90(4):404-411. [PubMed]
• Spano B, Giulietti G, Pisani V, Morreale M, Tuzzi E, Nocentini U, Francia A, Caltagirone C, Bozzali M, Cercignani M (2018). Disruption of neurite morphology parallels MS progression. Neurol Neuroimmunol Neuroinflamm 5(6):e502. [PubMed]
• Jones DK, Alexander DC, Bowtell R, Cercignani M, Dell'Acqua F, McHugh DJ, Miller KL, Palombo M, Parker GJM, Rudrapatna US, Tax CMW (2018). Microstructural imaging of the human brain with a 'super-scanner': 10 key advantages of ultra-strong gradients for diffusion MRI. Neuroimage 182:8-38. [PubMed]
• Makovac E, Serra L, Di Domenico C, Marra C, Caltagirone C, Cercignani M, Bozzali M (2018). Quantitative Magnetization Transfer of White Matter Tracts Correlates with Diffusion Tensor Imaging Indices in Predicting the Conversion from Mild Cognitive Impairment to Alzheimer's Disease. J Alzheimers Dis 63(2):561-575. [PubMed]
• Giulietti G, Torso M, Serra L, Spano B, Marra C, Caltagirone C, Cercignani M, Bozzali M (2018). Whole brain white matter histogram analysis of diffusion tensor imaging data detects microstructural damage in mild cognitive impairment and alzheimer's disease patients. J Magn Reson Imaging. [PubMed]
• Cercignani M, Gandini Wheeler-Kingshott C (2019). From micro- to macro-structures in multiple sclerosis: what is the added value of diffusion imaging. NMR Biomed 32(4):e3888. [PubMed]
• Dowell NG, Bouyagoub S, Tibble J, Voon V, Cercignani M, Harrison NA (2019). Interferon-alpha-Induced Changes in NODDI Predispose to the Development of Fatigue. Neuroscience 403:111-117. [PubMed]
• Olivito G, Lupo M, Iacobacci C, Clausi S, Romano S, Masciullo M, Molinari M, Cercignani M, Bozzali M, Leggio M (2017). Microstructural MRI Basis of the Cognitive Functions in Patients with Spinocerebellar Ataxia Type 2. Neuroscience 366:44-53. [PubMed]
• Serra L, Gabrielli GB, Tuzzi E, Spano B, Giulietti G, Failoni V, Marra C, Caltagirone C, Koch G, Cercignani M, Bozzali M (2017). Damage to the Frontal Aslant Tract Accounts for Visuo-Constructive Deficits in Alzheimer's Disease. J Alzheimers Dis 60(3):1015-1024. [PubMed]
• Mancini M, Giulietti G, Dowell N, Spano B, Harrison N, Bozzali M, Cercignani M (2018). Introducing axonal myelination in connectomics: A preliminary analysis of g-ratio distribution in healthy subjects. Neuroimage 182:351-359. [PubMed]
• Olivito G, Dayan M, Battistoni V, Clausi S, Cercignani M, Molinari M, Leggio M, Bozzali M (2017). Bilateral effects of unilateral cerebellar lesions as detected by voxel based morphometry and diffusion imaging. PLoS One 12(7):e0180439. [PubMed]
• Rae CL, Davies G, Garfinkel SN, Gabel MC, Dowell NG, Cercignani M, Seth AK, Greenwood KE, Medford N, Critchley HD (2017). Deficits in Neurite Density Underlie White Matter Structure Abnormalities in First-Episode Psychosis. Biol Psychiatry 82(10):716-725. [PubMed]
• Morris LS, Dowell NG, Cercignani M, Harrison NA, Voon V (2018). Binge drinking differentially affects cortical and subcortical microstructure. Addict Biol 23(1):403-411. [PubMed]
• Dayan M, Olivito G, Molinari M, Cercignani M, Bozzali M, Leggio M (2016). Impact of cerebellar atrophy on cortical gray matter and cerebellar peduncles as assessed by voxel-based morphometry and high angular resolution diffusion imaging. Funct Neurol 31(4):239-248. [PubMed]
• Meijer KA, Cercignani M, Muhlert N, Sethi V, Chard D, Geurts JJ, Ciccarelli O (2016). Patterns of white matter damage are non-random and associated with cognitive function in secondary progressive multiple sclerosis. Neuroimage Clin 12:123-31. [PubMed]
• Bozzali M, Serra L, Cercignani M (2016). Quantitative MRI to understand Alzheimer's disease pathophysiology. Curr Opin Neurol 29(4):437-44. [PubMed]
• Meijer KA, Muhlert N, Cercignani M, Sethi V, Ron MA, Thompson AJ, Miller DH, Chard D, Geurts JJ, Ciccarelli O (2016). White matter tract abnormalities are associated with cognitive dysfunction in secondary progressive multiple sclerosis. Mult Scler 22(11):1429-1437. [PubMed]
• Smith KW, Gierski F, Andre J, Dowell NG, Cercignani M, Naassila M, Duka T (2017). Altered white matter integrity in whole brain and segments of corpus callosum, in young social drinkers with binge drinking pattern. Addict Biol 22(2):490-501. [PubMed]
• Serra L, Petrucci A, Spano B, Torso M, Olivito G, Lispi L, Costanzi-Porrini S, Giulietti G, Koch G, Giacanelli M, Caltagirone C, Cercignani M, Bozzali M (2015). How genetics affects the brain to produce higher-level dysfunctions in myotonic dystrophy type 1. Funct Neurol 30(1):21-31. [PubMed]
• Mastropasqua C, Bozzali M, Spano B, Koch G, Cercignani M (2015). Functional Anatomy of the Thalamus as a Model of Integrated Structural and Functional Connectivity of the Human Brain In Vivo. Brain Topogr 28(4):548-58. [PubMed]
• Serra L, Cercignani M, Carlesimo GA, Fadda L, Tini N, Giulietti G, Caltagirone C, Bozzali M (2014). Connectivity-based parcellation of the thalamus explains specific cognitive and behavioural symptoms in patients with bilateral thalamic infarct. PLoS One 8(6):e64578. [PubMed]
• Bodini B, Cercignani M, Toosy A, De Stefano N, Miller DH, Thompson AJ, Ciccarelli O (2014). A novel approach with "skeletonised MTR" measures tract-specific microstructural changes in early primary-progressive MS. Hum Brain Mapp 35(2):723-33. [PubMed]
• Bozzali M, MacPherson SE, Cercignani M, Crum WR, Shallice T, Rees JH (2012). White matter integrity assessed by diffusion tensor tractography in a patient with a large tumor mass but minimal clinical and neuropsychological deficits. Funct Neurol 27(4):239-46. [PubMed]
• Prosperini L, Sbardella E, Raz E, Cercignani M, Tona F, Bozzali M, Petsas N, Pozzilli C, Pantano P (2013). Multiple sclerosis: white and gray matter damage associated with balance deficit detected at static posturography. Radiology 268(1):181-9. [PubMed]
• Bozzali M, Spano B, Parker GJ, Giulietti G, Castelli M, Basile B, Rossi S, Serra L, Magnani G, Nocentini U, Caltagirone C, Centonze D, Cercignani M (2013). Anatomical brain connectivity can assess cognitive dysfunction in multiple sclerosis. Mult Scler 19(9):1161-8. [PubMed]
• Wheeler-Kingshott CA, Ciccarelli O, Schneider T, Alexander DC, Cercignani M (2012). A new approach to structural integrity assessment based on axial and radial diffusivities. Funct Neurol 27(2):85-90. [PubMed]
• Bozzali M, Mastropasqua C, Cercignani M, Giulietti G, Bonni S, Caltagirone C, Koch G (2012). Microstructural damage of the posterior corpus callosum contributes to the clinical severity of neglect. PLoS One 7(10):e48079. [PubMed]
• Bozzali M, Battistoni V, Premi E, Alberici A, Giulietti G, Archetti S, Turla M, Gasparotti R, Cercignani M, Padovani A, Borroni B (2013). Structural brain signature of FTLD driven by Granulin mutation. J Alzheimers Dis 33(2):483-94. [PubMed]
• Bozzali M, Parker GJ, Spano B, Serra L, Giulietti G, Perri R, Magnani G, Marra C, G Vita M, Caltagirone C, Cercignani M (2013). Brain tissue modifications induced by cholinergic therapy in Alzheimer's disease. Hum Brain Mapp 34(12):3158-67. [PubMed]
• Cercignani M, Embleton K, Parker GJ, Bozzali M (2012). Group-averaged anatomical connectivity mapping for improved human white matter pathway visualisation. NMR Biomed 25(11):1224-33. [PubMed]
• Bodini B, Cercignani M, Khaleeli Z, Miller DH, Ron M, Penny S, Thompson AJ, Ciccarelli O (2013). Corpus callosum damage predicts disability progression and cognitive dysfunction in primary-progressive MS after five years. Hum Brain Mapp 34(5):1163-72. [PubMed]
• Serra L, Cercignani M, Basile B, Spano B, Perri R, Fadda L, Marra C, Giubilei F, Caltagirone C, Bozzali M (2012). White matter damage along the uncinate fasciculus contributes to cognitive decline in AD and DLB. Curr Alzheimer Res 9(3):326-33. [PubMed]
• Koch G, Cercignani M, Bonni S, Giacobbe V, Bucchi G, Versace V, Caltagirone C, Bozzali M (2011). Asymmetry of parietal interhemispheric connections in humans. J Neurosci 31(24):8967-75. [PubMed]
• Bozzali M, Giulietti G, Basile B, Serra L, Spano B, Perri R, Giubilei F, Marra C, Caltagirone C, Cercignani M (2012). Damage to the cingulum contributes to Alzheimer's disease pathophysiology by deafferentation mechanism. Hum Brain Mapp 33(6):1295-308. [PubMed]
• Jones DK, Cercignani M (2010). Twenty-five pitfalls in the analysis of diffusion MRI data. NMR Biomed 23(7):803-20. [PubMed]
• Raz E, Cercignani M, Sbardella E, Totaro P, Pozzilli C, Bozzali M, Pantano P (2010). Gray- and white-matter changes 1 year after first clinical episode of multiple sclerosis: MR imaging. Radiology 257(2):448-54. [PubMed]
• Bozzali M, Parker GJ, Serra L, Embleton K, Gili T, Perri R, Caltagirone C, Cercignani M (2011). Anatomical connectivity mapping: a new tool to assess brain disconnection in Alzheimer's disease. Neuroimage 54(3):2045-51. [PubMed]
• Scola E, Bozzali M, Agosta F, Magnani G, Franceschi M, Sormani MP, Cercignani M, Pagani E, Falautano M, Filippi M, Falini A (2010). A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up. J Neurol Neurosurg Psychiatry 81(7):798-805. [PubMed]
• Koch G, Cercignani M, Pecchioli C, Versace V, Oliveri M, Caltagirone C, Rothwell J, Bozzali M (2010). In vivo definition of parieto-motor connections involved in planning of grasping movements. Neuroimage 51(1):300-12. [PubMed]
• Serra L, Cercignani M, Lenzi D, Perri R, Fadda L, Caltagirone C, Macaluso E, Bozzali M (2010). Grey and white matter changes at different stages of Alzheimer's disease. J Alzheimers Dis 19(1):147-59. [PubMed]
• Raz E, Cercignani M, Sbardella E, Totaro P, Pozzilli C, Bozzali M, Pantano P (2010). Clinically isolated syndrome suggestive of multiple sclerosis: voxelwise regional investigation of white and gray matter. Radiology 254(1):227-34. [PubMed]
• Spano B, Cercignani M, Basile B, Romano S, Mannu R, Centonze D, Caltagirone C, Bramanti P, Nocentini U, Bozzali M (2010). Multiparametric MR investigation of the motor pyramidal system in patients with 'truly benign' multiple sclerosis. Mult Scler 16(2):178-88. [PubMed]
• Yogarajah M, Focke NK, Bonelli S, Cercignani M, Acheson J, Parker GJ, Alexander DC, McEvoy AW, Symms MR, Koepp MJ, Duncan JS (2009). Defining Meyer's loop-temporal lobe resections, visual field deficits and diffusion tensor tractography. Brain 132(Pt 6):1656-68. [PubMed]
• Wheeler-Kingshott CA, Cercignani M (2009). About "axial" and "radial" diffusivities. Magn Reson Med 61(5):1255-60. [PubMed]
• Bodini B, Khaleeli Z, Cercignani M, Miller DH, Thompson AJ, Ciccarelli O (2009). Exploring the relationship between white matter and gray matter damage in early primary progressive multiple sclerosis: an in vivo study with TBSS and VBM. Hum Brain Mapp 30(9):2852-61. [PubMed]
• Fasano F, Bozzali M, Cercignani M, Hagberg GE (2009). A highly sensitive radial diffusion measurement method for white matter tract investigation. Magn Reson Imaging 27(4):519-30. [PubMed]
• Bruno S, Cercignani M, Ron MA (2008). White matter abnormalities in bipolar disorder: a voxel-based diffusion tensor imaging study. Bipolar Disord 10(4):460-8. [PubMed]
• Bozzali M, Cercignani M, Baglio F, Scotti G, Farina E, Pugnetti L, Ashburner J, Nemni R, Falini A (2008). Voxel-wise analysis of diffusion tensor MRI improves the confidence of diagnosis of corticobasal degeneration non-invasively. Parkinsonism Relat Disord 14(5):436-9. [PubMed]
• Tofts PS, Jackson JS, Tozer DJ, Cercignani M, Keir G, MacManus DG, Ridgway GR, Ridha BH, Schmierer K, Siddique D, Thornton JS, Wroe SJ, Fox NC (2008). Imaging cadavers: cold FLAIR and noninvasive brain thermometry using CSF diffusion. Magn Reson Med 59(1):190-5. [PubMed]
• Price G, Cercignani M, Parker GJ, Altmann DR, Barnes TR, Barker GJ, Joyce EM, Ron MA (2008). White matter tracts in first-episode psychosis: a DTI tractography study of the uncinate fasciculus. Neuroimage 39(3):949-55. [PubMed]
• Ciccarelli O, Wheeler-Kingshott CA, McLean MA, Cercignani M, Wimpey K, Miller DH, Thompson AJ (2007). Spinal cord spectroscopy and diffusion-based tractography to assess acute disability in multiple sclerosis. Brain 130(Pt 8):2220-31. [PubMed]
• Price G, Cercignani M, Parker GJ, Altmann DR, Barnes TR, Barker GJ, Joyce EM, Ron MA (2007). Abnormal brain connectivity in first-episode psychosis: a diffusion MRI tractography study of the corpus callosum. Neuroimage 35(2):458-66. [PubMed]
• Flugel D, Cercignani M, Symms MR, O'Toole A, Thompson PJ, Koepp MJ, Foong J (2006). Diffusion tensor imaging findings and their correlation with neuropsychological deficits in patients with temporal lobe epilepsy and interictal psychosis. Epilepsia 47(5):941-4. [PubMed]
• Sastre-Garriga J, Ingle GT, Rovaris M, Tellez N, Jasperse B, Altmann DR, Benedetti B, Stevenson VL, Cercignani M, Leary SM, Barkhof F, Brochet B, Dousset V, Filippi M, Montalban X, Kalkers NF, Polman CH, Rovira A, Miller DH, Thompson AJ (2005). Long-term clinical outcome of primary progressive MS: predictive value of clinical and MRI data. Neurology 65(4):633-5. [PubMed]
• Jones DK, Symms MR, Cercignani M, Howard RJ (2005). The effect of filter size on VBM analyses of DT-MRI data. Neuroimage 26(2):546-54. [PubMed]
• Bozzali M, Falini A, Cercignani M, Baglio F, Farina E, Alberoni M, Vezzulli P, Olivotto F, Mantovani F, Shallice T, Scotti G, Canal N, Nemni R (2005). Brain tissue damage in dementia with Lewy bodies: an in vivo diffusion tensor MRI study. Brain 128(Pt 7):1595-604. [PubMed]
• Price G, Bagary MS, Cercignani M, Altmann DR, Ron MA (2005). The corpus callosum in first episode schizophrenia: a diffusion tensor imaging study. J Neurol Neurosurg Psychiatry 76(4):585-7. [PubMed]
• Cercignani M, Horsfield MA, Agosta F, Filippi M (2003). Sensitivity-encoded diffusion tensor MR imaging of the cervical cord. AJNR Am J Neuroradiol 24(6):1254-6. [PubMed]
• Rovaris M, Iannucci G, Cercignani M, Sormani MP, De Stefano N, Gerevini S, Comi G, Filippi M (2003). Age-related changes in conventional, magnetization transfer, and diffusion-tensor MR imaging findings: study with whole-brain tissue histogram analysis. Radiology 227(3):731-8. [PubMed]
• Cercignani M, Bammer R, Sormani MP, Fazekas F, Filippi M (2003). Inter-sequence and inter-imaging unit variability of diffusion tensor MR imaging histogram-derived metrics of the brain in healthy volunteers. AJNR Am J Neuroradiol 24(4):638-43. [PubMed]
• Cercignani M, Bozzali M, Iannucci G, Comi G, Filippi M (2002). Intra-voxel and inter-voxel coherence in patients with multiple sclerosis assessed using diffusion tensor MRI. J Neurol 249(7):875-83. [PubMed]
• Bozzali M, Cercignani M, Sormani MP, Comi G, Filippi M (2002). Quantification of brain gray matter damage in different MS phenotypes by use of diffusion tensor MR imaging. AJNR Am J Neuroradiol 23(6):985-8. [PubMed]
• Bozzali M, Falini A, Franceschi M, Cercignani M, Zuffi M, Scotti G, Comi G, Filippi M (2002). White matter damage in Alzheimer's disease assessed in vivo using diffusion tensor magnetic resonance imaging. J Neurol Neurosurg Psychiatry 72(6):742-6. [PubMed]
• Cercignani M, Inglese M, Siger-Zajdel M, Filippi M (2001). Segmenting brain white matter, gray matter and cerebro-spinal fluid using diffusion tensor-MRI derived indices. Magn Reson Imaging 19(9):1167-72. [PubMed]
• Bozzali M, Franceschi M, Falini A, Pontesilli S, Cercignani M, Magnani G, Scotti G, Comi G, Filippi M (2001). Quantification of tissue damage in AD using diffusion tensor and magnetization transfer MRI. Neurology 57(6):1135-7. [PubMed]
• Cercignani M, Inglese M, Pagani E, Comi G, Filippi M (2001). Mean diffusivity and fractional anisotropy histograms of patients with multiple sclerosis. AJNR Am J Neuroradiol 22(5):952-8. [PubMed]
• Cercignani M, Horsfield MA (2001). The physical basis of diffusion-weighted MRI. J Neurol Sci 186 Suppl 1:S11-4. [PubMed]
• Cercignani M, Bozzali M, Iannucci G, Comi G, Filippi M (2001). Magnetisation transfer ratio and mean diffusivity of normal appearing white and grey matter from patients with multiple sclerosis. J Neurol Neurosurg Psychiatry 70(3):311-7. [PubMed]
• Filippi M, Cercignani M, Inglese M, Horsfield MA, Comi G (2001). Diffusion tensor magnetic resonance imaging in multiple sclerosis. Neurology 56(3):304-11. [PubMed]
• Rocca MA, Cercignani M, Iannucci G, Comi G, Filippi M (2000). Weekly diffusion-weighted imaging of normal-appearing white matter in MS. Neurology 55(6):882-4. [PubMed]
• Filippi M, Iannucci G, Cercignani M, Assunta Rocca M, Pratesi A, Comi G (2000). A quantitative study of water diffusion in multiple sclerosis lesions and normal-appearing white matter using echo-planar imaging. Arch Neurol 57(7):1017-21. [PubMed]
• Ferini-Strambi L, Bozzali M, Cercignani M, Oldani A, Zucconi M, Filippi M (2000). Magnetization transfer and diffusion-weighted imaging in nocturnal frontal lobe epilepsy. Neurology 54(12):2331-3. [PubMed]
• Cercignani M, Iannucci G, Rocca MA, Comi G, Horsfield MA, Filippi M (2000). Pathologic damage in MS assessed by diffusion-weighted and magnetization transfer MRI. Neurology 54(5):1139-44. [PubMed]
• Cercignani M, Iannucci G, Filippi M (1999). Diffusion-weighted imaging in multiple sclerosis. Ital J Neurol Sci 20(5 Suppl):S246-9. [PubMed]
• Cercignani M, Horsfield MA (1999). An optimized pulse sequence for isotropically weighted diffusion imaging. J Magn Reson 140(1):58-68. [PubMed]